I absolutely have and used it for a while before landing on opensuse microos primarily. I absolutely see the benefit and enjoyed the git-centric nature, keeping flakes in repos with a flavor for each machine. What I didn’t enjoy, however, was the seemingly poor documentation. Quite frankly too, the drama surrounding the community doesn’t inspire confidence either. I decided I ought to try out guix but haven’t gotten to it yet. I do actually still have one nixos VM that hosts some services for me and is built entirely on the concept of the impermanence flake. That was pretty cool.

Nix OS is way more pain than it is worth for me.

There are plenty of alternatives that are much simpler. I prefer just a Debian install managed with tools like Ansible and pyinfra