I am not sure if I have a Treatment Resistant Depression, but I sure have been on multiple SSRIS for the last 10 years.

I honestly don’t feel any of them have “really worked” besides being numb.

I want to stop taking them eventually, wondering if Ketamine would open me in therapy and make it more meaningful/impacting.

I’m a really anxious person, so the thought of trying Ket or psychedelics always gets me nervous, like permanently making my anxiety worse or wake up some schizophrenia (I have no signs, nor I have relatives)

I know that attentiveness and dopamine regulation won’t improve with ket, but has anyone else been able to treat the depression and anxiety that comes with ADHD?

  • popcap200@lemmy.ml
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    9 months ago

    Have you tried ADHD specific non-stinulant medications to see if they help your depression/anxiety? Strattera really helped mine, and so did Guanfacine. Could also try Wellbutrin too, which didn’t work for me.

    • Retreaux@lemmy.world
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      8 months ago

      I was on Wellbutrin too, but it didn’t help the ADHD enough, despite improvements in mood. I’m currently on straterra because the scheduled stuff made me nervous. I think it’s working, but it’s subtle so sometimes I’m not sure.

      • popcap200@lemmy.ml
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        8 months ago

        What dosage are you at? I personally for myself had to be on 80mg for it to be really noticeable, even then I never had the energy to get anything done when I was just on strattera and not a stimulant.

        Why does the scheduled stuff make you nervous? Usually with ADHD, stimulants can help prevent addiction issues down the road, among other benefits. Also, some of them like Vyvanse and Concerta were designed to prevent dependencies forming with the prescription itself.

  • Tedrow@lemmy.world
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    9 months ago

    You may already know this but it isn’t clear from your post. Depression doesn’t come with ADHD, it is caused the effects of ADHD. Like, you get depressed because ADHD makes life harder. I would recommend trying to treat your ADHD first and see if that helps. This can help improve self esteem. If that does help your depression you may need a separate treatment.

    You definitely need to speak with a psychiatrist though. Some cases require immediate treatment of depression, which is really how I’ve seen ketamine being used.

    • Rhynoplaz@lemmy.world
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      9 months ago

      The lack of dopamine from everyday events can feel like depression. There have been times that I was just so bored of everything and I sat around doing nothing all day. Then thinking back on the wasted day, is kind of depressing.

  • gingersneak@lemmy.world
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    9 months ago

    I am doing Ketamine therapy for treatment resistant depression and SI. It worked miracles for the SI, that’s almost completely gone. For depression it helps a lot, but that’s not going to just go away. If nothing else has helped, I would recommend it. Seriously talk with a real psychiatrist first. They do want you to dissociate though, but it’s a pretty harmless feeling for me. I wouldn’t have anxiety about it, it’s not going to completely rewrite your psyche lol.

  • qooqie@lemmy.world
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    9 months ago

    So talk to a psychiatrist about this. Not an NP or other, a real psychiatrist.

    However, I do know ketamine is useful for TRD, and it’s low dose no need to worry about tripping balls. Electroshock therapy is another useful tool for TRD. Finally Auvelity is a new med that is real good for TRD and depression in general. All are really good, and reported positively by patients.

    As for making your anxiety worse? Doubtful. Awakening schizophrenia? Not how it develops so no chance of that.

    • diannetea@lemmy.world
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      9 months ago

      I would add to look into transcranial magnetic stimulation as well, it has an insane rate of success.

      I’ve recently been referred to a major hospital that offers this, ketamine, and electroshock therapy, I’m still waiting to be scheduled but I have a long documented history of treatment resistant depression and the many medications I’ve tried. I’ve had severe depression for over 25 years now, I’m exhausted and finally have hope for relief.