Sometimes not even that.

My friend takes anti-depressants, but they make her lethargic and apathetic, so that added amphetamines so counteract the lethargy.

Yeah, she’s been through the gamut of antidepressants. That’s the other thing: it’s just a big crap shoot. Sometimes you go through 6 different medications before you find one that works and has side effects you can live with.