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The Picard Maneuver@lemmy.world to Microblog Memes@lemmy.worldEnglish · 24 days ago

It's hard to say goodbye

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It's hard to say goodbye

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The Picard Maneuver@lemmy.world to Microblog Memes@lemmy.worldEnglish · 24 days ago
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  • Cryophilia@lemmy.world
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    24 days ago

    You think that cloud of smoke coming out of people’s mouth is oil?

    • Baguette@lemm.ee
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      24 days ago

      I don’t care about vapes, but not everyone wants secondhand smoke

      Shit lingers for a while too

      There’s a reason why we did away with the tobacco designated areas in buildings, the same applies to vapes

      • Cryophilia@lemmy.world
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        24 days ago

        It’s literally not smoke, that’s what I’m saying. It’s fucking water vapor. There’s no harm, and it’s literally undetectable aside from a brief smell of whatever it’s flavored with.

        Equating vapes with tobacco is so stupid. There is zero (0) tobacco in a vape.

        • andros_rex@lemmy.world
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          24 days ago

          Are you in middle school?

          It’s not water vapor.

          • Cryophilia@lemmy.world
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            24 days ago

            The other stuff in vape clouds is such an infinitesimally small amount, it’s really not worth considering. On the order of like <400 migrograms per gram of vape cloud, with the average vape cloud mass being <100mg

            Wikipedia

            Study that I was able to access through my university

            The scientific failings of nearly all research into e-cigs is a big pet peeve of mine. So, so many studies with abstracts and titles shouting VAPES WILL LITERALLY KILL YOU AND YOUR CHILDREN IF YOU LOOK AT THEM and then when you dig into the results it’s less harmful than ambient air in a Walmart.

            • andros_rex@lemmy.world
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              23 days ago

              Only up to 100 mg? Such a tiny amount of substance could never have an impact on a human body! That’s why when I take a 50 mg edible absolutely nothing happens.

              You are delusional, and completely misinterpreting that study and Wikipedia. Like, reading your other comment you did a “lot of work” on - I’m kind of amazed - it reminds me of the kind of stuff that I’d see to back up Ivermectin being a miracle cure.

              Nicotine induces epithelial–mesenchymal transition (EMT), which is one of the vital steps for the acquisition of malignant phenotype. This transition allows the cell to acquire migratory properties, which may facilitate cancer metastases (42). Nicotine decreases the tumor suppressor Chk2, which is activated by DNA damage. The decrease in Chk2 in cells exposed to nicotine suggests that nicotine may be capable of overriding DNA damage checkpoint activation, disrupting genetic surveillance, and increasing the risk of oncogenesis (43).

              Since you seem very concerned with dosage:

              Systemic intake of nicotine from standardized vaping and smoking sessions after overnight abstinence from nicotine has been estimated from area under the nicotine plasma concentration-time curve (AUC).50 Average nicotine intake from e-cigarettes was 0.9 mg compared to 2.2 mg from a cigarette. Nicotine intake was higher, averaging 1.8 mg, from variable power e-cigarettes. It is difficult to extrapolate from nicotine in the liquid to systemic dose. For example, assuming 1 to 1.5 mg nicotine per cigarette, a 5% nicotine JUUL pod containing 0.7 ml liquid with 59 mg/ml nicotine, or 41 mg nicotine, would equate to 27 to 41 cigarette equivalents. However, using both emission data in laboratory testing and human exposure studies, one 5% JUUL pod seems to be equivalent in systemic nicotine delivery to smoking around 18 cigarettes per day.51

              Secondhand smoke is also harmful:

              Prevalence of secondhand nicotine vape increased from 11.7% to 15.6% during the study period in this population. Prevalence of wheeze, bronchitic symptoms and shortness of breath ranged from 12.3% to 14.9%, 19.4% to 26.0% and 16.5% to 18.1%, respectively, during the study period. Associations of secondhand nicotine vape exposure with bronchitic symptoms (OR 1.40, 95% CI 1.06 to 1.84) and shortness of breath (OR 1.53, 95% CI 1.06 to 2.21) were observed after controlling for vaping, active and passive exposure to tobacco or cannabis, and demographic characteristics (age, gender, race/ethnicity and parental education). Stronger associations were observed when analysis was restricted to participants who were neither smokers nor vapers. There were no associations with wheezing after adjustment for confounders.

              You have an addiction and are doing something that is harmful to your body. There is not an evil conspiracy by the government and research scientists to convince you that nicotine is bad for you, nicotine is bad for you.

              • Cryophilia@lemmy.world
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                23 days ago

                Oh Christ on a cracker, I don’t have time to explain how math works

                Only up to 100 mg? Such a tiny amount of substance

                The entire cloud, water vapor and all, is up to 100mg, dumbass. It’s like 0.04mg of chemicals in the biggest vape clouds. That’s nothing.

                • andros_rex@lemmy.world
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                  23 days ago

                  Can you read that middle study for me friendo?

                  I know you don’t have time to explain how math works, but can you explain the concepts of p-value and statistical significance for me?

                  Also, do things existing at less than 0.04 mg have no effect on the human body?

                  • Cryophilia@lemmy.world
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                    23 days ago

                    can you explain the concepts of p-value and statistical significance for me?

                    Literally irrelevant to the point I’m making.

                    Also, do things existing at less than 0.04 mg have no effect on the human body?

                    In almost every case, that’s correct.

                    Keep in mind that’s also the strongest measured concentration of the biggest clouds in the whole study, and that assumes instead of passively breathing in someone else’s vape cloud, they’re just breathing the whole thing right into your mouth. Realistic amounts of chemicals would be an order or two magnitude lower.

            • 𝓔𝓶𝓶𝓲𝓮@lemm.ee
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              23 days ago

              You are right but you still will be stoned for saying the truth. Those ppl probably breathe in much more harmful shit daily without second thoughts

              This comment section makes me want to start to vape again

        • Baguette@lemm.ee
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          24 days ago

          Dude I’m talking about smoke from vapes as in vape cloud, mist, whatever you wanna call it. It’s still secondhand, and it still lingers in the air long enough for other people to breathe it in. I can tell when someone took a hit even if I didn’t see them puff it because it doesn’t just straight up disappear immediately and like 99% is like cotton candy or some other sweet flavor that is super distinctive in smell. If you ever lived in cali you’d know exactly what I’m talking about. Obviously it doesn’t stay for years or anything, hell it usually clears up after like a couple of minutes at worst, but to say it’s undetectable is just false.

          I’m obviously not talking about the same smoke as tobacco, that shit is like tar and reeks for years. I’m also not saying there’s tobacco in vapes, I just said the reason why we don’t allow smoking inside is because of tobacco, and for good reason.

          • Cryophilia@lemmy.world
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            23 days ago

            And my point is that vaping isn’t smoking and shouldn’t be subject to the same ban. Vaping doesn’t leave residue or discolor walls or any of the other nasty shit that tobacco does. The vape cloud doesn’t linger like smoke. And secondhand vaping isn’t even a thing, it’s like secondhand breathing. It’s just flavored water vapor, there’s no other chemicals or stuff in the cloud.

            Edit: no other chemicals at harmful levels, technically there’s an almost imperceptibly small amount of stuff in there but it’s roughly equivalent to ambient air in a city

        • RedC@sh.itjust.works
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          24 days ago

          Yes but there IS nicotine in most vapes, which is the harmful part

          • Cryophilia@lemmy.world
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            24 days ago

            That crazy myth needs to die. Nicotine is approximately as harmful as caffeine. Highly addictive but not particularly harmful itself. Tobacco and all the chemicals they put in cigarettes are the stuff that gives you cancer.

            • andros_rex@lemmy.world
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              24 days ago

              Nicotine poses several health hazards. There is an increased risk of cardiovascular, respiratory, gastrointestinal disorders. There is decreased immune response and it also poses ill impacts on the reproductive health. It affects the cell proliferation, oxidative stress, apoptosis, DNA mutation by various mechanisms which leads to cancer. It also affects the tumor proliferation and metastasis and causes resistance to chemo and radio therapeutic agents.

              […]

              In normal cells, nicotine can stimulate properties consistent with cell transformation and the early stages of cancer formation, such as increased cell proliferation, decreased cellular dependence on the extracellular matrix for survival, and decreased contact inhibition. Thus, the induced activation of nAChRs in lung and other tissues by nicotine can promote carcinogenesis by causing DNA mutations. Through its tumor promoter effects, it acts synergistically with other carcinogens from automobile exhausts or wood burning and potentially shorten the induction period of cancers.

              • Cryophilia@lemmy.world
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                24 days ago

                Ooh boy, it’s time to link to my favorite “I did a lot of work and no one responded” pair of posts, with a deep dive into how the NIH and other offices’ claims about nicotine are utter bullshit and a great example of the failures of the modern scientific apparatus: https://lemmy.world/post/16434400/10677530

                My favorite parts:

                There’s stuff like this heart.org result, which exclusively talk about “smoking and nicotine”. These types of articles are dangerous in and of themselves because they require a level of critical thinking to separate out “smoking” and “nicotine”. A lot of anti-vaping hit pieces have a top-level title talking about nicotine, but then the body of the article references negative effects that are exclusive to smoking. Here’s one such hit piece, run by a dystopian-sounding group called the “Truth Initiative” which should immediately make anyone suspicious of their goals. Note the article is under topic “harmful effects of tobacco”, subtopic “nicotine addiction”.

                So like, they took the high end of that study they referenced, increased it a little, used that as the low end of their study, made their high end 4 times that, and then gave that amount to a fucking mouse injected with a human tumor. And then did it again, 5 more times a day. And then said that “mimicked the daily intakes of cigarettes in smokers”. HAH.

                Side note: see how incestuous this all is? We have a study of studies (NIH) referencing a study of studies (Jensen) referencing a study of studies (Chowdhury), referencing…nothing at all.

                • andros_rex@lemmy.world
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                  23 days ago

                  ”study of studies”

                  Yes my sweet child - that is called a meta-analysis.

                  • Cryophilia@lemmy.world
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                    23 days ago

                    Yeah no fucking shit, Sherlock

            • Scubus@sh.itjust.works
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              24 days ago

              They hated him because he spoke the truth

            • braxy29@lemmy.world
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              24 days ago

              be me, sneaking outside at work to vape while my coworker brings a literal gallon of coffee everyday.

              nicotine certainly has been demonized in the last few decades.

              • Cryophilia@lemmy.world
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                24 days ago

                I saw a great long-form article with a theory that I don’t completely buy into but is very interesting.

                In 1998, a MASSIVE lawsuit against the tobacco companies was settled. The result was the Master Settlement Agreement (MSA). Due to the harmful public health effects of tobacco, cigarette companies were required to pay huge sums to the state governments, in perpetuity, based on the level of sales of cigarettes. To be clear, this was a great and reasonable idea, given the public health costs associated with smoking (funny enough, since then, costs have lowered on average as people live longer but smokers don’t).

                Several states then “securitized” their future payments and sold them off to get short-term injections of cash. If the term “securitization” seems familiar, it’s the craze that led to the financial collapse in 2008, when people were securitizing junk mortgages. As part of these tobacco bond securitization agreements, states have to pay their business partners a certain dollar amount every year going forward, NOT based on the level of sales of cigarettes.

                Then, for a variety of reasons including vaping, cigarette sales started to tank. Meaning states were getting less money from the MSA, but they still owed the same amount to their debtors. Many of these bonds are in junk status, and some states are realistically looking at bankruptcy due to that stupid decision 20 years ago. There’s $97 billion they owe in total, and most states have no way to pay it.

                So now we have a large number of state governments with an extremely powerful financial incentive to suppress vaping and encourage cigarette smoking.

                • andros_rex@lemmy.world
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                  23 days ago

                  This is a conspiracy theory.

                  This is no different from being an anti-vaxxer or Ivermectin nut. You are selectively reading bits of studies that you are not understanding, and do not have basic knowledge of how statistics or the human body work.

                  • Cryophilia@lemmy.world
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                    23 days ago

                    Like I said, I don’t fully buy into it, but the facts are incontrovertible and it’s a fairly compelling argument.

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