I always start by cleaning the contact patches on the board and the rubber domes below the buttons. They’re prone to getting corroded and/or packed full of crud if the Gameboy (or controller, or whatever) has been stored carelessly for a long time.

I’ve fixed several with that issue.

Is there any visible corrosion on the board? Any damage?

If not, then the contact points probably need a good cleaning with rubbing alcohol.

You can also try cleaning the silicone pads with rubbing alcohol, but you might need new pads.